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Mold: An Underestimated Factor in Hashimoto’s Disease

September 16, 2024

For many individuals with Hashimoto’s disease, dietary factors often play a significant role in the onset and progression of hypothyroidism. Identifying and eliminating these dietary triggers can be crucial for achieving healing and even remission. However, it's important to recognize that other toxins, sometimes less apparent, can also contribute to the autoimmune response. One such factor that is not commonly discussed is mold.

While not everyone is affected by mold exposure, a surprising number of individuals experience a decline in health, manifesting in respiratory, digestive, and cognitive symptoms, due to toxic mold. 

UNDERSTANDING MOLD

Mold, a type of fungi, is a naturally occurring element in our environment. It thrives in areas where oxygen and moisture are present, spreading through the air via spores—its reproductive cells.

Mold tends to hide in damp, dark areas of the home, such as bathrooms, kitchens, basements, or any space that has recently experienced flooding. It can also be found under sinks and in poorly ventilated spaces. Outdoors, mold commonly resides in moist soil and decaying organic materials. High concentrations of mold spores in the air are a frequent cause of environmental allergic reactions. Indoors, mold can settle on building materials, carpeting, and even food, particularly when moisture is present. Accumulation often occurs after a flood or due to unaddressed water leaks.

Although mold is pervasive in our surroundings, significant health issues generally arise from exposure to large quantities. Indoors, the most commonly encountered molds include Cladosporium, Penicillium, Alternaria, and Aspergillus. Health problems associated with indoor mold exposure range from asthma attacks and sinus infections to headaches, dizziness, and skin rashes.

Certain molds produce toxic secondary metabolites known as mycotoxins, which can lead to severe health problems for both humans and animals. These are often referred to as “toxic molds,” with exposure to mycotoxins being linked to neurological issues and even fatalities.

One of the most notorious toxic molds is Stachybotrys chartarum—commonly known as “black mold.” It typically grows on household surfaces such as wood, fiberboard, gypsum board, paper, dust, and lint.

MOLD: A POSSIBLE UNDERLYING CAUSE OF SYMPTOMS

There is extensive peer-reviewed research highlighting the detrimental effects that “black molds” can have on the brain and immune system. Notably, Dr. Enusha Karunasena, a leading mold researcher, has shown that these molds can compromise the endothelial cells that form the blood-brain barrier. As these cells serve as the brain's primary defense against external threats, any damage to them can allow toxic molds to infiltrate the brain and harm neurons.

This breach of the blood-brain barrier can also permit substances, typically harmless to other parts of the body, to enter the brain and cause further neuronal damage. Consequently, individuals who have suffered from such damage due to toxic mold exposure may develop sensitivities to a wide range of substances, from wood smoke to air fresheners. Mold toxicity is also a potential environmental trigger for Hashimoto’s symptoms, a topic I will explore further.

It is crucial to recognize, however, that not all molds are harmful. Molds play vital roles in various processes, including pharmaceutical and food production. For instance, penicillin, soy sauce, and blue cheese are products of mold activity. Yet, for those sensitive to mold, even minimal exposure—such as that found in cheese, nuts, or coffee—can provoke adverse reactions.

SYMPTOMS OF MOLD TOXICITY

The effects of mold exposure can vary significantly from person to person. Even within the same household, individuals may exhibit different symptoms depending on their genetic makeup. While some family members may develop immune-related illnesses, others might remain symptom-free.

Common symptoms associated with mold exposure include brain fog, respiratory difficulties, cognitive decline, immune system suppression, chronic fatigue, depression, arthritis, digestive disturbances, poor sleep, inflammation, and joint pain.

For those with a mold allergy, symptoms may include: 

  • Watery, itchy eyes
  • Persistent coughing
  • Headaches or migraines
  • Difficulty breathing
  • Skin rashes
  • Fatigue
  • Sinus congestion or nasal blockages
  • Frequent sneezing

Some of my patients, who were previously fit and athletic, have experienced rapid weight gain and severe inflammation following mold exposure, leading to noticeable physical changes within just a few months.

THE CONNECTION BETWEEN MOLD AND HASHIMOTO’S DISEASE

Mold exposure can be a significant trigger for Hashimoto’s disease, asthma, and other autoimmune conditions. While I’ve encountered a few stories of Hashimoto’s remission in individuals also affected by mold, it was startling to learn that up to 45 million people worldwide may be impacted by mold exposure.

One potential indicator that mold might be the root cause of health issues is when a person's health declines after moving into a new home. In a 2015 survey of the Hashimoto’s community, 20 percent of respondents reported that their health began to deteriorate following a move.

It’s important to understand that mold exposure does not affect everyone similarly. Depending on an individual’s genetic predisposition, they might develop severe asthma, experience mild symptoms like sneezing, or remain entirely unaffected.

The mold Aspergillus, commonly found indoors, has been identified in studies as a cause of thyroiditis in immunosuppressed individuals. In one study, up to 20 percent of those affected by a disseminated disease had thyroids infiltrated by the Aspergillus mold.

Another study found that patients who developed chronic illness after exposure to water-damaged buildings and mold had detectable levels of mycotoxins in their urine. The study concluded that mold can persist in the body, continually releasing mycotoxins that contribute to ongoing chronic illness, with the sinuses being a primary reservoir for these molds and mycotoxins.

Various infections, including those caused by mold, can lead to sinus problems. These sinus infections can then drain into the gut, causing intestinal permeability, also known as “leaky gut” syndrome. Mold-induced “leaky gut” can become a significant trigger for autoimmune conditions like Hashimoto’s. In fact, I’ve observed cases where Hashimoto’s has gone into remission after effectively treating sinus infections.

MOLD IN THE HOME

If you suspect mold exposure, it's crucial to test both your home environment and your body to determine if molds are present.

As previously mentioned, mold commonly thrives in dark, damp areas with limited ventilation, such as bathrooms, basements, and locations that have experienced flooding. A stale, moldy odor often indicates the presence of mold. While a visual inspection can sometimes reveal mold, not all mold spores are visible to the naked eye. Mold can also hide behind walls and under flooring, making it essential to conduct an air quality test to accurately detect its presence in your home.

Additional areas in the home that may harbor mold include:

  • Houseplants
  • Christmas trees
  • Carpeting
  • HVAC filters
  • Closets
  • Cardboard boxes
  • Washing machines
  • Water pipes

The term "toxic black mold" might lead some to believe that all toxic molds are black and easily noticeable. However, this is a misconception. Many molds are invisible to the eye and can appear in various colors.

To identify the presence of mold in a building, an air sample is typically collected using a specialized pump that gathers airborne spores. A laboratory then analyzes the sample to determine both the concentration and types of molds present.

Mold testing can be performed by a professional service, but there are also home testing kits available that allow you to check for mold yourself. These kits can be purchased from sources like Real Time Laboratories, with results sent directly to you.

MOLD PREVENTION

To prevent mold growth in your home or workspace, consider the following steps:

  1. Eliminate Moisture Sources: Address and fix any sources of uncontrolled moisture, such as roof leaks, pipe leaks, or flooding.
  1. Control Humidity Levels: Keep indoor humidity levels below 40 percent to inhibit mold growth.
  1. Maintain HVAC Systems: Clean all heat/air ductwork systems every two years and inspect the ductwork seals, repairing them if necessary.
  1. Use Non-Toxic Sprays: Apply a non-toxic, bio-balancing spray, like Citrisafe, into the intakes of your duct system once or twice a week. As the unit pulls in air, the spray circulates and minimizes mold growth.
  1. Install Anti-Microbial Filters: Use anti-microbial filters in your HVAC intakes to kill mold spores.
  1. Replace Cardboard with Plastic: Get rid of cardboard boxes, as mold feeds on the wood pulp used in cardboard. Store items in plastic containers instead, especially in under-ventilated spaces like garages and closets.
  1. Optimize Closet Ventilation: Avoid packing clothing articles too tightly in closets to allow for proper air circulation.
  1. Manage Washer and Dryer Moisture: Leave the doors of your washer and dryer open when not in use, and spray them with a bio-balancing spray like Citrisafe after each use.
  1. Enhance Air Circulation: Avoid cluttering corners and areas around furniture, as these spaces can collect dust and harbor mold.
  1. Improve Bathroom Ventilation: Increase ventilation in bathrooms by opening windows or turning on the fan to help remove moisture during and after use.
  1. Insulate Cold Water Pipes: Insulate cold water pipes to prevent sweating and water dripping, which can contribute to mold growth.
  1. Seal Gaps Around Pipes and Electrical Fixtures: Seal all pipes entering through flooring or walls, such as under the kitchen counter, with caulking. Do the same with metal boxes of electrical plugs and light switches.
  1. Limit Indoor Plants: Houseplants can easily grow mold, so limit their number. However, some plants have been found by NASA to remove harmful chemicals from the air, such as formaldehyde and benzene. The following plants are helpful:
    • Bamboo Palm (Chamaedorea seifritzii)
    • Chinese Evergreen (Aglaonema modestum)
    • English Ivy (Hedera helix)
    • Gerbera Daisy (Gerbera jamesonii)
    • Janet Craig (Dracaena “Janet Craig”)
    • Marginata (Dracaena marginata)
    • Mass Cane/Corn Plant (Dracaena massangeana)
    • Mother-in-Law’s Tongue (Sansevieria laurentii)
    • Pot Mum (Chrysanthemum morifolium)
    • Peace Lily (Spathiphyllum “Mauna Loa”)
    • Warneckii (Dracaena “Warneckii”)

MOLD IN THE BODY

Testing for mold in your home environment is just as important as testing your body for the presence of molds.

Functional medicine testing can help determine whether mold from your environment has migrated into your body, particularly into your intestines. Stool tests, like the GI MAP test and the GI Effects test, may sometimes reveal mold and fungi in the stool. If detected, this indicates the need for deeper testing to identify the specific type of mold a person has been colonized by or exposed to.

Here are my go-to tests for detecting mold in the body:

  • MyMycoLab: MyMycoLab is a laboratory specializing in blood serum antibody testing for mycotoxins. Our laboratory tests for 14 different mycotoxins for both IgG and IgE antibodies. This is the most precise and accurate method to determine if a person has been exposed to mycotoxins.
  • Organic Acids Test (OAT) from Mosaic Diagnostics (formerly known as Great Plains Laboratory): This screening test can reveal if mold has colonized your body, providing a broad view of your internal mold exposure.
  • MycoTOX Profile by Mosaic Diagnostics: This comprehensive test screens for 11 different mycotoxins from 40 species of mold using a single urine sample. It employs advanced mass spectrometry (MS/MS) to detect even low levels of these fungal toxins. The MycoTOX Profile is particularly useful for follow-up testing to ensure that detoxification therapies have been successful.

TREATMENTS TO ELIMINATE MOLD

If you've been exposed to mold, it’s crucial to understand that mold may have also settled within your body. Eliminating exposure to mold is an essential first step in recovering from mold toxicity.

Steps to Eliminate Mold from Your Environment:

  • Remove the Source: Address and rectify any sources of mold in your home or workspace to prevent further exposure.
  • Consult a Professional: Engage professionals to thoroughly inspect and remediate mold issues in your environment.

Additional Interventions for Mold Removal from the Body:

  • Seek a provider experienced in diagnosing and detoxifying mold toxicity.
  • Address Sinus Infections: Mold exposure can lead to sinus infections (sinusitis), which may contribute to conditions like Hashimoto’s. A study by the Mayo Clinic found that moldy environments were responsible for 90% of chronic sinus issues.
  • Treat Intestinal Permeability: Mold in the sinuses and intestines can cause intestinal permeability, also known as “leaky gut.” This condition can trigger autoimmune diseases. Comprehensive treatment to restore gut health and repair the intestinal barrier may be necessary.
  • Detoxification Therapies: Implement detoxification protocols tailored to eliminate mold and its mycotoxins from the body. This may include specific dietary changes, supplements, and medications designed to support the body’s natural detoxification processes.

FUNGAL SINUSITIS

For years, sinus infections were primarily attributed to bacteria or viruses. However, recent research has recognized that fungi, such as mold, can also cause sinus infections, particularly in individuals with suppressed immune systems. The sinus cavity, with its damp and dark environment, can be an ideal habitat for fungal growth.

Distinguishing Fungal Sinusitis from Other Types:

Fungal sinus infections can be challenging to differentiate from those caused by bacteria or viruses since the symptoms are quite similar: headaches, sinus pressure, congestion, and discolored discharge. Additionally, sinus infections may have multiple causes, including a combination of fungi, bacteria, and viruses.

Recognizing Allergic Fungal Sinusitis:

Allergic fungal sinusitis was identified as a distinct condition around a decade ago and accounts for approximately 6-8% of all chronic sinusitis cases requiring surgical intervention. While certain symptoms may suggest allergic fungal sinusitis, there are no standardized diagnostic criteria. Accurate diagnosis is critical as treatment and prognosis for fungal sinusitis can differ significantly from chronic bacterial sinusitis.

In some cases, treating fungal sinusitis effectively can lead to the reversal of Hashimoto’s.

Treatment Options:

Fluconazole has shown promise as a treatment for persistent fungal sinusitis infections. In a recent study, 16 patients with allergic fungal sinusitis were treated with fluconazole nasal spray, leading to improvement in 12 of the 16 patients without significant side effects. Larger studies are needed to confirm these findings, but the results suggest that fluconazole may benefit those with allergic fungal sinusitis.

Itraconazole is an effective option for treating mycotoxins in the sinuses and body. Your provider can also work with a compounding pharmacy to create customized nasal sprays tailored to your specific needs or infections.

Testing for Fungal Sinusitis:

To determine if a sinus infection is caused by mold, specific tests can be performed:

  • MARCoNS Test: Detects mold-related bacterial infections and fungi in the sinuses.
  • CT Scan: A cross-sectional imaging test used by an ear, nose, and throat specialist to identify fungal or bacterial infections in the sinuses.

Symptoms of Chronic Sinusitis:

Pain in the sinuses, nose, ear, face, or throat; drainage from the nose; headaches; chronic cough; post-nasal drip; sneezing; congestion; throat irritation; loss of smell; and ear inflammation. A fever may also be present but can be less noticeable in thyroid disease.

At Gandhi Health & Wellness, I prioritize starting with natural supplements for treating fungal sinusitis, reserving prescription medications as a secondary option if necessary. Below is a list of both approaches.

Recommended Supplements:

  • Argentyn 23 Nasal Spray
  • Oil of Oregano
  • S. Boulardii
  • Activated Charcoal
  • Berberine 
  • Caprylic Acid 
  • Olive (Olea europaea) Leaf Extract 
  • Grapefruit (Citrus paradisi) Seed Extract 
  • Garlic (Allium sativum) Bulb 
  • Neem Leaf 
  • Thyme (Thymus vulgaris) Aerial Extract 

Treatment is customized based on each patient's mycotoxin results, age, and overall health, allowing for a personalized plan tailored to their specific needs.

Prescription Medications:

  • Fluconazole: Targets mold in the sinuses and throughout the body.
  • Cholestyramine: Binds mold in the body.
  • Nystatin Oral: Treats mold in the gut.
  • Fluconazole: Targets mold in the sinuses and throughout the body.
  • Cholestyramine: Binds mold in the body.
  • Nystatin Oral: Treats mold in the gut.
  • Nystatin Nasal Flush: Compounded medication used with a NasoNeb for fungal infections in the sinuses.
  • Itraconazole 
  • Prescription Nasal Spray: Compounded medication with Sporanox, Xylitol, Bactroban, and Beclometasone to treat both fungal and bacterial infections in the sinuses.

Additional Recommendations:

  • Nasal Rinse: Use a neti pot once or twice daily to help clear mold spores and toxins from the nasal passages.
  • Optimize Gut Health: Address any gut health issues that may contribute to mold toxicity, as a healthy gut is crucial for effective detoxification and immune support.
  • Candida Overgrowth: Candida yeast can co-occur with mold toxicity. Implementing protocols to eliminate Candida may be necessary alongside mold treatments to prevent reinfection and support overall health.
  • Sauna Therapy: Regular sauna sessions, particularly infrared sauna, can support the detoxification process by promoting sweating, which helps eliminate mycotoxins stored in the body’s tissues. Saunas also improve circulation, support the immune system, and may help reduce symptoms associated with mold exposure. Start with shorter sessions and gradually increase the duration as tolerated, ensuring adequate hydration and mineral support.

For personalized support in managing fungal infections and mold-related conditions, you may benefit from consulting a functional medicine practitioner. As a Board Certified Primary Care Physician and Functional Medicine provider at Gandhi Health and Wellness in South Florida, I specialize in addressing these issues and would be happy to help you explore effective treatment options.

ADDITIONAL LIFESTYLE INTERVENTIONS

Whether you’ve experienced mold toxicity or simply want to minimize exposure, there are several strategies to protect both your living environment and your body from excessive mold.

Dietary Interventions

Certain foods are more likely to be contaminated with molds, which can increase the toxic burden on your body. While some mold contamination is visible, such as white fuzz on old leftovers, other moldy foods are not easily detectable but can still be problematic if consumed regularly.

Common Mold-Contaminated Foods:

  • Coffee
  • Aged Cheeses
  • Alcoholic Beverages
  • Wine Vinegar
  • Condiments
  • Processed Meats
  • Mushrooms
  • Packaged Fruit Juices
  • Dried Fruit
  • Leftovers (consume within 24 hours or freeze)
  • Overripe Fruit and Vegetables (avoid wilted, discolored, or mushy produce)
  • Bread
  • Tomato Products
  • Multi-B Vitamins
  • Products of Aspergillus Fermentation (soy sauce, chocolate, black tea, malt extract, Lactaid, citric acid)

Shopping Tips:

  • Frequent Purchases: Food will mold over time, so shop frequently and buy in smaller quantities.
  • Check Freshness: When in doubt, ask vendors about the freshness of their products.
  • Organic Foods: Be aware that organic foods may mold more quickly.

Diet Recommendations:

Following a diet that minimizes mold-containing foods can help in reducing mold exposure. For example, many of the foods listed above are avoided in specific low-mold diet plans.

By incorporating these lifestyle changes, you can better manage mold exposure and its potential impacts on your health. For personalized guidance on managing mold in your diet and overall health, feel free to reach out. As a Board Certified Primary Care Physician and Functional Medicine provider at Gandhi Health and Wellness in South Florida, I can provide tailored advice to help you effectively address these concerns.

Environmental Interventions

If you’ve discovered mold in your home, it’s essential to address the issue promptly to prevent ongoing health risks. Professional mold remediation services are often necessary to safely remove contaminated parts of your home and ensure that the source of exposure is eliminated. Otherwise, you risk recontamination and the continuation of mold toxicity.

Professional Mold Remediation

  • Hire Professionals: Engage a certified mold remediation service to handle mold removal safely and effectively. These experts will help remove contaminated materials and address the underlying issues causing mold growth.
  • EPA Resources: Visit the Environmental Protection Agency (EPA) website for detailed information on detecting mold, cleaning methods, and finding professional mold removal services.

Extreme Cases

In severe cases, it may be necessary to dispose of belongings that are heavily contaminated with mold to avoid recontamination. While this might seem drastic, removing mold triggers from your environment is crucial for your health.

Pre-Purchase Inspections

If you’re buying a new home or workspace, have it inspected by a professional mold detection service to ensure there are no hidden mold issues.

Maintaining a Mold-Free Environment

  • Keep Spaces Dry: Address any flooding or water leaks immediately to prevent mold growth. Maintaining dryness in your living space is key.
  • Regular Air Duct Cleaning: Clean your air ducts semi-annually to prevent the accumulation of mold spores.
  • Probiotic Cleaning Spray: Use a probiotic cleaning spray, such as Homebiotics, to kill mold and bacteria on household surfaces. It’s naturally derived and safe for use around children and pets.
  • Quality Air Filter: Invest in a high-quality air filter, such as the Air Doctor, to purify your air from airborne molds and allergens. Many users, including those with asthma, have found it beneficial in reducing symptoms.

By implementing these environmental interventions, you can significantly reduce the risk of mold exposure and maintain a healthier living environment.

PATH TO HEALTH: MANAGING MOLD EFFECTIVELY 

Mold is an unwelcome substance that can hide in your home and your body, but identifying and addressing it is crucial for your health. Discovering and managing mold may be a key step in recovering your health and potentially putting Hashimoto’s into remission.

Steps to Take:

  1. Test and Eliminate: Begin by testing your home and workspace for mold, and take immediate action to remove any contamination. Preventing future mold growth is essential for maintaining a healthy environment.
  1. Body Testing and Treatment: If mold is present in your environment, consider further testing to determine if mold has affected your body. Implement a protocol of supplements and pharmaceuticals as needed to clear mold from your system.
  1. Ongoing Vigilance: Continuously monitor and prevent mold in your living spaces. Regular maintenance and preventative measures will help safeguard your health.

By addressing both environmental and personal mold exposure, you can make significant strides in improving your health and managing thyroid conditions. Keep exploring and addressing the root causes of your health issues to restore your vitality and well-being.

If you suspect you're dealing with mold-related health issues, including fungal sinusitis or Hashimoto's, call Gandhi Health & Wellness at 561-247-3311 to schedule a consultation and take the first step toward better health.


Disclosure: This content is adapted from information previously provided by Dr. Izabella Wentz, PharmD, which can be accessed in its original form here. The insights and recommendations have been modified to incorporate Dr. Kunal Gandhi's perspectives and updates, adding further clarity and relevance to current discussions on mold toxicity and health.

About Dr. Kunal P. Gandhi:

Dr. Kunal P. Gandhi is a board-certified family medicine expert and distinguished functional medicine practitioner with a deep commitment to uncovering the root causes of illnesses. Specializing in hormonal imbalances, Dr. Gandhi takes a comprehensive, root-cause-centered approach that addresses foundational imbalances rather than just symptoms. Leveraging extensive knowledge and advanced laboratory testing, she delivers personalized care, including specialized detoxification programs and solutions for issues such as hormonal imbalances, intestinal dysbiosis, Lyme disease, and more.

About Gandhi Health & Wellness:

Gandhi Health & Wellness in Palm Beach County is dedicated to providing a holistic, root-cause approach to healthcare. Under the expert guidance of Dr. Kunal P. Gandhi, a board-certified family medicine and functional medicine practitioner, the practice focuses on uncovering and addressing the underlying causes of health issues, with a particular emphasis on hormonal imbalances. We offer personalized care plans that integrate advanced laboratory testing, specialized detoxification programs, and treatments for conditions such as intestinal dysbiosis and Lyme disease. At Gandhi Health & Wellness, our mission is to empower patients to achieve optimal health and well-being through comprehensive, individualized care.